POSTDOCTORAL SCHOLAR - ANESTHESIA - SMITH LAB

Research in the Smith lab focuses on the acute inflammation and endothelial response to acute surgical stress. Clinical outcomes of interest include postoperative acute kidney injury and delirium. Study techniques include clinical studies of surgical patients, in vivo mechanistic studies (mice), and in vitro human primary cell experiments. Current studies focus on single-cell spatial transcriptomic characterization of the human endothelial response to surgery including cell-cell interaction prediction modeling as well as characterization of the surgically triggered "genomic storm" in human PBMCs and endothelial cells. The laboratory also has ongoing projects examining the protective role of high-density lipoproteins in these biological pathways and processes, with the goal of developing novel lipoprotein-based therapies for perioperative protection. Fellows' research in the Smith lab is well-support by a team of clinical research nurses and coordinators along with an excellent laboratory technician. Additionally, throughout the completion of their research projects, fellows in the Smith lab have the opportunity to work one on one with the PhD biostatistician associated with our laboratory to learn introductory machine learning methodology such as latent variable mixture modelling if desired. The Smith laboratory recognized the need for fellows to develop an independent national and international research reputation and has financial resources to support their presentation of their research at national research meetings. Completion of a post-doctoral fellowship in the Smith lab will produce a highly-marketable, well-rounded translational researcher positioned to excel in a variety of desirable career settings including academics and industry.

PhD degree in a field related to molecular medicine

• Excellent interpersonal skills, English writing skills, laboratory skills, and analytic skills.
• Applicants will be expected to play a lead role in current research projects and clinical studies, including patient enrollment and sample collection and processing, and will be supported by a clinical research team of nurses and research coordinators as well as by a laboratory technician. Applicants will also have the opportunity to develop independent research projects related to their own interests.
• Applicants will be expected to be able to work independently and will also be expected to be able to effectively collaborate with multiple research groups within and outside our world-class institution.
• Graduate transcript with grades averaging B or greater on the USA scale.

• Experience in a wide range of wet-lab and computational methods including but not limited to next-generation sequencing and data analysis, spatial transcriptomic sequencingand analysis, single-cell studies, advanced cell culture techniques, DNA/RNA work, immunostaining, and animal husbandry (mice).
• Experience with endothelial biology and/or lipoprotein biology.
• Completion of a PhD program with an expected training time greater than 2 years.
• Two or more first author original research publications in impact factor 5 or above journals related to medical or human biology research.
• Have obtained some external research funding during their graduate training.
• Reference from a laboratory manager or equivalent support position the applicant has directly worked with within the past 3 years for a minimum of 1 year.

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