Principal Scientist I

At Roche, we are passionate about transforming patients' lives and are bold in both decision and action. We believe that good business means a better world. That is why we come to work each day, committed to scientific rigor, unassailable ethics, and ensuring access to medical innovations for all. We do this today to build a better tomorrow.

We are seeking a highly motivated and innovative Principal Scientist to join our Molecular Diagnostics R&D team in Pleasanton, CA. This is a hands-on, lab-based role where you will serve as a subject matter expert in PCR technology, driving the development of next-generation molecular diagnostic assays.

Your mission will be to lead the design, optimization, and validation of novel PCR-based assays for our diagnostic platforms. You will translate complex scientific concepts into robust and reliable products that have a direct impact on patient care. This is an opportunity for a visionary scientist to not only pioneer new workflows but to help shape the future of molecular diagnostics at Roche.

As a Principal Scientist, you will lead from the bench and be a key technical leader and contributor within a dynamic, cross-functional team. Your responsibilities will include:

• Assay Development: Lead the design and development of PCR and/or digital PCR (dPCR) assays for molecular diagnostic applications. This includes primer/probe design, reaction buffer optimization, and protocol establishment.

• Optimization & Troubleshooting: Independently design and execute rigorous experiments (including DOE, or Design of Experiments) to optimize assay performance, robustness, and cost-effectiveness. Act as the primary technical expert for troubleshooting complex assay and instrument-related issues.

• Product Development: Drive R&D activities within a regulated product development framework (e.g., Design Control). Contribute to all phases of product development, from feasibility and proof-of-concept to verification, validation, and transfer to manufacturing.

• Data Analysis: Perform in-depth statistical analysis and interpretation of complex experimental data. You will be responsible for drawing sound scientific conclusions and making data-driven recommendations.

• Communication & Collaboration: Clearly and effectively communicate findings, progress, and strategic recommendations to project teams, R&D leadership, and non-technical stakeholders. Author technical reports, validation documents, and SOPs.

• Mentorship: Provide technical guidance and mentorship to junior scientists, fostering a culture of scientific rigor, innovation, and collaboration.

You are a self-motivated, hands-on scientist who thrives in a fast-paced, collaborative environment. You approach complex problems with a sense of urgency, optimism, and deep scientific curiosity.

• A degree in Molecular Biology, Biochemistry, Genetics, or a related scientific field with the following experience:

• Bachelor's with at least 10 years of relevant industry experience.

• Master's with at least 7 years of relevant industry experience.

• PhD with at least 3-5 years of relevant industry experience.

• Profound understanding of PCR technology (qPCR, RT-qPCR) and its application in molecular diagnostics.

• Demonstrated hands-on experience in PCR assay design, optimization, and validation.

• Proven experience working within a molecular diagnostic product development environment.

• Strong data analysis skills using statistical software (e.g., JMP, R) and proficiency in data interpretation.

• Excellent interpersonal, presentation, and communication skills, with a proven ability to collaborate effectively across multidisciplinary teams.

• Hands-on experience with digital PCR (dPCR) platforms and a strong understanding of dPCR applications in molecular diagnostics (e.g., oncology, infectious disease).

• Experience working under a regulated environment (e.g., IVD, FDA, CE-IVD) and familiarity with Design Control principles.

• Experience of working as a technical project lead and interfacing with a multifunction team.

• A track record of innovation as demonstrated by publications, patents, or successful product launches.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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