Scientist, Molecular Pathology Lab

Overview:

The Pathology team is seeking a Molecular Pathology Scientist. Experience performing and evaluating immunohistochemistry and/or in situ hybridization is essential. Interpretation of labeled specimens requires an understanding of anatomy and histology and an ability to identify specific cell populations in tissue sections. Quantitative morphometrics and/or AI-assisted image analysis will be a component of the role. Multiple imaging modalities will be employed including chromogenic and multiplex fluorescence microscopy, spatial-seq, and when applicable confocal and electron microscopy.

This position is onsite and will be primarily located in Cambridge, MA.

Responsibilities:

Laboratory Expertise:

• Conduct antibody optimization for immunohistochemistry.
• Perform immunohistochemical and in-situ hybridization procedures to include multiomic staining protocols using the Leica BOND and/or Discovery ULTRA staining platform.
• Analyze and evaluate assays for sensitivity and specificity.
• Mount, label and distribute or scan prepared microscope slides to pathologists or to appropriate areas for interpretation.
• Quantitative morphometrics and/or AI-assisted image analysis will be a component of the role. Multiple imaging modalities will be employed including chromogenic and multiplex fluorescence microscopy, spatial-seq, and when applicable confocal and electron microscopy.
• Responsible for maintaining reagents, preventative maintenance procedures and troubleshooting for relevant equipment.
• Proficiency in tissue trimming/embedding and microtome/cryostat tissue sectioning.
• Maintain regulatory compliance and SOPs.
• Cross-functional collaboration with the research group and broadly with other departments throughout the company.
• Ensures compliance and alignment with all EH and S initiatives within the Molecular Pathology Laboratory.
• Operateswithin a quality management system and collaborates with quality assurance and regulatory team to improve laboratory processes, optimize methods, and develop quality analytics.
• Experience with online ordering of lab materials, reagents, as well as maintaining inventory of lab supplies.
• Ensure ELN (electronic lab notebooks) are kept up to date in a complete and consistent manner, following all legal requirements as well as keeping clear and complete record.
• Support validation of new assays and instruments for molecular histology.

Scientific & Technical Leadership:

• Maintain knowledge of scientific technological developments by reading the current literature and attending professional conferences to develop innovative concepts, which may lead to new assays, equipment requests, and/or procedures.
• Participate in planning and execution of Early Development (eDEV) and Research projects.
• In collaboration with pathologists, may present experimental results to senior scientific staff.
• May prepare and/or contribute to articles for publication.
• Develop relationships with teams within eDEV and broader ReDev (Research Development) to enhance collaboration and streamline processes.

Mentoring:

• Build collaborative relationships among team members and work cooperatively with others.
• Adapt well to change, and function well with ambiguity.
• Demonstrate the ability to manage conflict.

Qualifications:

• Bachelor's degree or higher in life sciences field with 8+ years of laboratory experience.
• ASCP Histotechnician certification(s).
• Experience routinely demonstrating initiative that has a direct impact on the pathology labs operation, improvement and refinement.
• Ability to communicate and present complex scientific information to scientific and non- scientific audiences.
• Ability to make decisions autonomously and requires minimal guidance to perform job duties.
• Communicate openly and directly with laboratory group, departmental and cross-functional scientific groups, and management.
• Proven project management skill set, evidenced by history of successful project delivery and successful timelines completed.
• Strong analytical, problem solving, and decision-making skills.

U.S. Pay Range

$110,400.00 - $165,600.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.