Research Postdoctoral Fellow - DeRaedt Lab

SHIFT:

Seeking Breakthrough Makers

Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career.

CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means.

A Brief Overview
Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.

This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

About the Laboratory

TheDeRaedtLab is located at the Children's Hospital Philadelphia and University of Pennsylvania, PA, USA. We aim todevelop novel, successful therapies, including cellular and immunotherapies, for children with brain tumors by dissecting the fundamental processes of tumor biology anddeveloping highly relevant mouse models.

Why join us?

High impact science: Cutting edge basic translational projects with a number of recent high profile publications (Nature Neuroscience, Molecular Cancer Therapeutics)

Focus: Neurofibromatosis type I associated gliomas and sporadic pediatric HGG

Goal: Elucidate what drives glioma to develop rational therapies and translate these findings into preclinical trials.

Research environment: We are part of the rich academic environment of the University of Pennsylvania, and have a direct connection to the Children's Hospital Philadelphia which allows us to rapidly translate any of our findings.

Ongoing projects:

Genetic drivers of NF1 HGG: Elucidating the role of additional genetic drivers in NF1 HGG (ATRX) by generating mouse models. MHCII antigen presentation/myeloid mimicry: Elucidate the role MHCII expression in NF1 HGG tumor cells (see poster ISPNO, Molecular Cancer Therapeutics) Advanced preclinical modeling: Optimizing tumoroid/organoid cultures for NF1 associated high- and low-grade glioma (see poster ISPNO). Next-Gen CAR-T therapies: Developing CAR-T therapies for NF1 associated malignancies (NF1 HGG, NF1 LGG and MPNST). We developed a unique pipeline that allows us to target internal proteins using CAR-T (see poster ISPNO). Cellular delivery vectors: Using migratory interneuron precursors as a cellular delivery vector for therapeutic proteins to glioma (see presentation ISPNO, accepted in Nature Neuroscience).

https://www.research.chop.edu/de-raedt-laboratory

What you will do

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects

Education Qualifications

• Doctorate - Required

Skills and Abilities

• Ability to wear a respirator device

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine. Learn more.

EEO / VEVRAA Federal Contractor | Tobacco Statement

SALARY RANGE:

Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.

-------------------

At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.